Research
Hormonal
Genetic disruption of core clock genes (e.g., Clock, Bmal1, Per) in mice leads to obesity, hyperphagia, and metabolic disorders, demonstrating a direct genetic link between circadian regulation and energy homeostasis.
Understand that your genetics play a role in how your body handles time and food. If you have a family history of metabolic issues, strict adherence to circadian hygiene (regular sleep/eating times) may be even more critical for you.
StrongSupportsHIGH confidence
Clock mutant mice are obese and hyperphagic... Global Bmal1 knockout mice are arrhythmic and display increased adiposity at early ages... mice with mutations in the Period genes display increased adiposity.
Why this rating
Based on well-established genetic animal models with clear phenotypic outcomes.
Source
Circadian rhythms, sleep, and metabolism
Wenyu Huang et al. · Journal of Clinical Investigation · 2011
narrative_reviewCited 713×
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