Hormonal
High-dose mazdutide (9-10 mg once-weekly) produces robust, statistically significant body weight loss (approx. 10-12%) in Chinese adults with overweight or obesity, with a favorable safety profile despite transient gastrointestinal side effects.
If you are an adult with overweight or obesity, once-weekly injections of mazdutide (9-10 mg) can lead to significant weight loss (around 10%) over 3-4 months. While you may experience temporary stomach issues like nausea or diarrhea, these usually improve over time. This treatment is most effective when combined with maintaining your current diet and exercise habits.
The mean percent change from baseline to week 12 in body weight were -11.7% (SE 1.5) for participants receiving mazdutide in the 9 mg cohort... The mean percent change from baseline to week 16 in body weight were -9.5% (SE 1.7) for participants receiving mazdutide in the 10 mg cohort... Mazdutide dosed up to 9 mg and 10 mg was both well tolerated and showed a favourable safety profile.
Why this rating
Phase 1b trial, small sample size (n=24), short duration (12-16 weeks), but randomized and placebo-controlled.
Source
Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial
Linong Ji et al. · EClinicalMedicine · 2022
DOI 10.1016/j.eclinm.2022.101691
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