Research
Hormonal
Discontinuation of anti-obesity medications (AOMs) after weight loss leads to significant weight regain (approx. two-thirds of lost weight) and reversal of cardiometabolic improvements, necessitating long-term treatment.
Obesity is a chronic condition. If you stop taking your medication after losing weight, you will likely regain most of that weight (about two-thirds) and lose the health benefits. Treatment should be viewed as long-term management, similar to blood pressure medication, rather than a short-term fix.
StrongSupportsHIGH confidence
discontinuation of the drug and associated lifestyle intervention led to regain of two-thirds of the lost weight in the ensuing year, with similar reversion in improvements of cardiometabolic variables.
Why this rating
Based on extension trials (SURMOUNT-4, semaglutide extension).
Source
Approach to Obesity Treatment in Primary Care
Susan Z. Yanovski et al. · JAMA Internal Medicine · 2024
narrative_reviewCited 72×
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