Adherence
Discontinuation of GLP-1 therapy for obesity leads to significant weight regain (up to two-thirds of lost weight within one year), even when accompanied by conventional nutritional counseling, highlighting the need for long-term lifestyle support.
If you stop taking your GLP-1 medication, you will likely regain a significant portion of the weight you lost, even if you try to eat well. This is because the medication helps manage hunger signals that return when you stop taking it. To maintain your weight loss, you need a robust, long-term lifestyle plan, not just standard diet advice, and you may need to stay on the medication long-term.
When GLP-1s are discontinued, weight regain is common—with up to two-thirds of the lost weight regained within 1 y... Notably, this has been observed even with accompanying use of conventional nutritional counseling and/or behavioral therapy.
Why this rating
Based on observational studies and clinical trials cited (references 18-20).
Source
Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society
Dariush Mozaffarian et al. · American Journal of Clinical Nutrition · 2025
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