Research
Hormonal
The hypertrophic benefit of creatine supplementation is modestly greater in younger adults compared to older adults, although the effect remains small in both groups.
Younger lifters may see a slightly better muscle growth boost from creatine than older lifters, but the difference is small. Older adults should still use creatine as it provides a small benefit, even if the magnitude is lower than in youth.
GoodQualifiesMEDIUM confidence
Analyses of the moderating effects indicated a small superior benefit for creatine supplementation in younger compared to older adults (0.17 (95%CrI: −0.09 to 0.45)).
Why this rating
Based on subgroup analysis of the same high-quality meta-analysis.
Source
The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis
Ryan Burke et al. · Nutrients · 2023
DOI 10.3390/nu15092116
Meta-analysis · 10 studiesCited 65×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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