Hormonal
Chronic high-fat diet consumption increases the formation and activation of mTOR complexes 1 and 2 in skeletal muscle, leading to insulin resistance via S6K1-mediated inhibition of IRS1, whereas exercise training reverses this process by enhancing AMPK activation.
Chronic overconsumption of fats can trigger molecular switches (mTOR) in your muscles that block insulin, leading to resistance. Regular exercise acts as a counter-switch by activating AMPK, which turns off mTOR and restores insulin sensitivity. To maintain metabolic health, balance fat intake with consistent physical activity.
Our data implicates reductions in mTOR complex activation with the reversal of lipid-induced skeletal muscle insulin resistance in response to exercise training or AICAR and identifies mTOR as a potential target for the treatment of insulin resistance.
Why this rating
Strong experimental design with in vivo rat models, in vitro cell culture, and clear mechanistic pathways, though translated to humans.
Source
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
Donato A. Rivas et al. · Journal of Endocrinology · 2009
DOI 10.1677/joe-09-0202
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