Research
Hormonal
In older adults, higher age, greater adiposity, higher systolic blood pressure, lower HDL, and higher triglycerides are independently associated with greater insulin resistance but better beta-cell function.
In older adults, traditional cardiovascular risk factors like high blood pressure and high triglycerides correlate with higher insulin resistance but are paradoxically associated with better preserved beta-cell function.
GoodQualifiesHIGH confidence
older age, greater adiposity, higher systolic blood pressure, a lower high-density lipoprotein cholesterol level, a higher triglyceride level, and a lower alcohol intake to be independently associated with greater IR but, conversely, with better β-cell function (P < 0.001).
Why this rating
Large cohort, multivariable adjusted cross-sectional analysis.
Source
Risk Factors for Type 2 Diabetes Mellitus Preceded by β-Cell Dysfunction, Insulin Resistance, or Both in Older Adults
Fumiaki Imamura et al. · American Journal of Epidemiology · 2013
DOI 10.1093/aje/kws440
cohort · n=4384Cited 57×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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