Research
Hormonal
Obesity accelerates biological cardiovascular ageing by inducing structural and functional cardiac and vascular changes that mimic those of chronological ageing, independent of traditional risk factors.
Your heart ages based on how you treat it, not just your birth year. Obesity forces your heart to work harder and remodels it to look and function like an older, non-obese heart. Losing weight can reverse these changes, effectively turning back the biological clock of your cardiovascular system.
GoodSupportsHIGH confidence
Thus, obesity not only prematurely induces but also closely mimics the cardinal functional and structural characteristics of cardiac ageing.
Why this rating
Supported by multiple human cohort studies and animal models cited in the review.
Source
Obesity accelerates cardiovascular ageing
Celia Rupérez et al. · European Heart Journal · 2025
DOI 10.1093/eurheartj/ehaf216
narrative_reviewCited 47×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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