Research
Hormonal
Tirzepatide (a dual GIP/GLP-1 receptor agonist) facilitates the largest reduction in body weight and increases in health-related quality of life (QoL) among Type 2 Diabetes medications.
If weight loss and quality of life are your primary goals, Tirzepatide is the most effective medication identified in this analysis. It offers greater weight reduction and QoL improvements than standard GLP-1 RAs, though it may cause gastrointestinal side effects.
StrongSupportsHIGH confidence
Tirzepatide appears to facilitate the largest reduction in body weight and increase in health-related quality of life (QoL) in individuals with T2D [15] followed by varying effects of the individual GLP-1 receptor agonists.
Why this rating
Based on 821 trials, 471,815 patients, using GRADE assessment.
Source
Data from network meta-analyses can inform clinical practice guidelines and decision-making in diabetes management: perspectives of the taskforce of the guideline workshop
Antonio Ceriello et al. · Cardiovascular Diabetology · 2023
narrative_reviewCited 9×
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