Hormonal
Liraglutide-induced weight loss is significantly attenuated in individuals consuming high-carbohydrate diets when hepatic FGF21 signaling is absent, indicating that FGF21 mediates the appetite-suppressing effects of GLP-1 receptor agonists specifically in the context of high carbohydrate intake.
If you are using a GLP-1 receptor agonist like liraglutide, your weight loss results may be suboptimal if you consume a high-carbohydrate diet. This is because the drug relies on a hormone called FGF21 to help suppress appetite, and this hormone is most effective at reducing food intake when carbohydrates are present. To maximize weight loss, consider reducing your carbohydrate intake, as this may enhance the drug's ability to engage the FGF21 pathway and promote greater weight reduction.
Liraglutide-induced weight loss was impaired in LivFgf21(−/−) mice when fed HC and HFHS diets but not when fed a LC diet.
Why this rating
High-quality preclinical evidence using multiple knockout models and metabolic chambers, though results are specific to male mice.
Source
Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets
Thao D. V. Le et al. · Molecular Metabolism · 2023
DOI 10.1016/j.molmet.2023.101718
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