Macro partitioning
A three-week ketogenic diet (max 10% carbohydrates) significantly reduces serum insulin and triglycerides while increasing anti-inflammatory fatty acids (ETA, DHA) and ketone bodies in healthy adults.
To trigger these metabolic benefits, restrict carbohydrates to under 30g per day (approx 10% of calories) for at least three weeks. Focus on increasing fat and moderate protein intake. Monitor ketone levels to ensure you are in ketosis. This protocol significantly lowers insulin and triglycerides while boosting anti-inflammatory markers in healthy people.
KD led to a marked reduction of insulin (-21.45% ± 6.44%, p = 0.0038) and c-peptide levels... Serum triglyceride concentration decreased accordingly... increase of anti-inflammatory fatty acids eicosatetraenoic acid (p < 0.0001) and docosahexaenoic acid (p = 0.0002) was detected.
Why this rating
Prospective intervention study with n=40, rigorous metabolomic analysis, but short duration (3 weeks) and healthy population limits generalizability.
Source
A ketogenic diet substantially reshapes the human metabolome
David Effinger et al. · Clinical Nutrition · 2023
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