Hormonal
In non-obese adult humans, circulating leptin levels do not predict or influence adaptive variations in energy expenditure (resting metabolic rate, thermic effect of feeding, or total energy expenditure).
For healthy, non-obese adults, your circulating leptin levels do not dictate your metabolic rate or how many calories you burn through activity. Focus on maintaining muscle mass and physical activity, as these are the primary drivers of energy expenditure, rather than trying to manipulate leptin levels directly.
After statistically accounting for age, body fat, and fat free mass, there was no association between leptin and any measured energy expenditure parameter.
Why this rating
Study uses rigorous methods (doubly labeled water, indirect calorimetry) on a large, healthy, weight-stable cohort, though it is cross-sectional.
Source
Relationship Between Circulating Leptin and Energy Expenditure in Adult Men and Women Aged 18 Years to 81 Years
Susan B. Roberts et al. · Obesity Research · 1997
DOI 10.1002/j.1550-8528.1997.tb00671.x
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