Research
Macro partitioning
Rapid weight loss from GLP-1 and dual/triple agonists can lead to significant loss of lean muscle mass, necessitating strategies to preserve muscle.
While GLP-1 and dual/triple agonists are effective for fat loss, they can also cause significant muscle loss. Patients should consider resistance training and discuss muscle-preserving strategies with their healthcare provider.
GoodQualifiesHIGH confidence
Tirzepatide treatment resulted in -33.9% reduction in total body fat mass (vs -8.2% placebo) and reduced lean mass by -10.9% (vs -2.6% placebo).
Why this rating
Supported by DEXA data from the SURMOUNT-1 trial.
Source
G protein-coupled receptors and obesity
Alessandro Pocai · Frontiers in Endocrinology · 2023
narrative_reviewCited 9×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →