Research
Macro partitioning
Excess caloric intake, particularly from carbohydrates (fructose/glucose) and saturated fats, drives de novo lipogenesis and hepatic fat accumulation, whereas unsaturated fats (omega-3) may reduce liver fat.
Focus on reducing added sugars (especially fructose/sweetened beverages) and saturated fats. Replace them with unsaturated fats (like omega-3s) and whole food carbohydrates. Total calories matter, but what you eat matters more for your liver.
GoodSupportsHIGH confidence
Mechanistically, increased dietary intake of carbohydrate (increasing hepatic substrates for DNL) or FFAs may overwhelm the capacity to manage FFA hepatocyte flux, promoting NAFLD development. ... omega-3 PUFAs have been shown to reduce liver fat content when compared with olive oil [58], possibly via the suppression of hepatic DNL and concurrently increased fatty acid oxidation.
Why this rating
Supported by over-feeding trials, cross-sectional studies, and mechanistic reviews.
Source
Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives
Daniel Clayton‐Chubb et al. · Nutrients · 2023
narrative_reviewCited 38×
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