Hormonal

Chronic aerobic exercise training reverses high-fat diet-induced impairments in the compartmentalization and activation of insulin-signaling components (specifically aPKC and Akt2) in skeletal muscle, thereby restoring insulin-stimulated glucose transport.

If you have developed insulin resistance from a poor diet, consistent aerobic exercise (like brisk uphill walking or jogging) can restore your muscles' ability to respond to insulin. This happens by fixing how key signaling proteins move to the cell surface to let glucose in. Unlike some medications which may not fix these specific cellular defects, exercise directly corrects the machinery.