Hormonal
Tirzepatide, a dual GIP/GLP-1 receptor agonist, achieves greater glycemic control and weight loss compared to isolated GLP-1 receptor agonism.
For individuals with Type 2 Diabetes or obesity who need more than standard GLP-1 medications, Tirzepatide is a newer option that targets two hormone receptors (GIP and GLP-1). Clinical trials show it can lower blood sugar by more than 2% and achieve weight loss exceeding 15%, which is greater than what is typically seen with GLP-1-only drugs.
Tirzepatide has emerged as a dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA, with more striking effects on glycemic control and weight reduction than those achieved by isolated GLP-1R agonism alone. This consists of lowering glycated hemoglobin levels by more than 2% and weight loss exceeding 15% from baseline.
Why this rating
Supported by Phase 3 clinical trials (SURPASS, SURMOUNT) showing significant reductions in HbA1c and weight loss, though long-term cardiovascular outcome data is still emerging compared to GLP-1 RAs.
Source
Incretin‐based therapies for the management of cardiometabolic disease in the clinic: Past, present, and future
James P. Psaltis et al. · Medicinal Research Reviews · 2024
DOI 10.1002/med.22070
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