Hormonal
Setmelanotide, a melanocortin-4 receptor (MC4R) agonist, produces significant weight loss and reduced hunger in patients with severe obesity linked to specific genetic deficiencies (POMC, PCSK1, LEPR, BBS, Alström, SRC1, SH2B1).
For individuals with severe obesity caused by specific genetic mutations (like POMC or LEPR deficiencies), Setmelanotide is a highly effective treatment that significantly reduces body weight and hunger. It requires regular injections, and patients should be prepared for common side effects like skin darkening and injection site reactions, which are generally manageable. This treatment is specifically indicated for genetic forms of obesity, not general weight loss.
Our results support the use of setmelanotide in treating severe obesity... The mean difference in percentage (% mean) weight loss for the pooled data was −6.91%... and the mean percentage difference (% mean) in the decrease in the maximum hunger score for the grouped data was −35.6%.
Why this rating
Meta-analysis of 12 studies with GRADE rating of 'high' certainty for weight loss, though heterogeneity was high.
Source
Efficacy and Safety of Setmelanotide, a Melanocortin-4 Receptor Agonist, for Obese Patients: A Systematic Review and Meta-Analysis
Bárbara Ferraz Barbosa et al. · Journal of Personalized Medicine · 2023
DOI 10.3390/jpm13101460
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