Research
Hormonal
High-fat diets, specifically saturated lipids like palmitic acid, disturb gastrointestinal feedback and promote overconsumption independently of food palatability.
Be mindful of high-saturated-fat foods (like those high in palmitic acid). They can disrupt your body's natural 'fullness' signals, leading you to eat more than you need, regardless of how tasty they are. Balancing fats with fiber and protein can help mitigate this effect.
GoodSupportsHIGH confidence
Intragastric infusions of fat, but not of carbohydrates, have been shown to disturb GI feedback and promote overconsumption independently of palatability [30,82].
Why this rating
Cited from studies showing direct physiological effects of fat infusion.
Source
Neuroendocrine gut–brain signaling in obesity
Tim Gruber et al. · Trends in Endocrinology and Metabolism · 2024
DOI 10.1016/j.tem.2024.05.002
narrative_reviewCited 28×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Chronic consumption of high-calorie/obesogenic diets causes maladaptive perturbations in gut-brain signaling, leading to desensitization of vagal afferents and reduced efficacy of appetite-suppressing gut hormones (GLP-1, CCK, PYY), which contributes to the exacerbation of metabolic dysregulation and obesity.Good
- Consuming protein and/or fiber before carbohydrates (meal sequencing) enhances GLP-1 secretion, delays gastric emptying, and improves postprandial glucose and lipid metabolism compared to consuming carbohydrates first.Good
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