Hormonal
GLP-1 receptor agonists (GLP-1 RAs) improve sperm parameters (concentration, motility, morphology) and testosterone levels in obese men with metabolic hypogonadism, primarily through weight loss and direct testicular effects.
If you are obese and struggling with fertility, GLP-1 medications like semaglutide or liraglutide may help improve your sperm count and testosterone levels, not just by helping you lose weight, but potentially by directly supporting testicular function. The key is working with a doctor to start with a low dose and slowly increase it to minimize stomach issues. While these drugs are expensive, the potential for improved fertility and sustained weight loss might justify the cost compared to other treatments.
Recent clinical trials discussed in this review demonstrate weight loss associated with GLP-1 RAs is correlated with improvements in sperm count, concentration, and motility. ... Recent studies show that the use of GLP-1 RAs in obese males may enhance sperm metabolism, motility, and insulin secretion in vitro, along with positive effects on the human Sertoli cells.
Why this rating
The paper is a narrative review citing multiple small clinical trials and pre-clinical studies; no large-scale randomized controlled trials (RCTs) on fertility outcomes are presented.
Source
Impact of GLP-1 Agonists on Male Reproductive Health—A Narrative Review
Alexandra Aponte Varnum et al. · Medicina · 2023
DOI 10.3390/medicina60010050
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