Research
Hormonal
Delayed gastric emptying contributes to weight loss with GLP-1 agonists, but central appetite suppression is the predominant mechanism.
While GLP-1 drugs slow stomach emptying, this only explains about 20% of the weight loss. The main driver is reduced hunger and food intake due to brain signaling.
GoodQualifiesMEDIUM confidence
Overall, the central effects on appetite and food intake are the predominant mechanisms leading to weight loss... degree of gastric emptying delay may contribute around 20% of the variance in weight loss
Why this rating
Based on meta-analyses and specific mechanistic studies cited.
Source
Newer pharmacological interventions directed at gut hormones for obesity
Michael Camilleri et al. · British Journal of Pharmacology · 2023
DOI 10.1111/bph.16278
narrative_reviewCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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