Research
Hormonal
Once-weekly 2.4 mg semaglutide produces significant weight loss and cardiometabolic improvements in adults with obesity, regardless of whether the treatment is combined with standard or very intensive lifestyle interventions.
Take 2.4 mg of semaglutide once weekly, starting with a low dose (0.25 mg) and increasing every 4 weeks to minimize side effects. While you should still eat healthy and exercise, do not expect lifestyle changes to significantly boost weight loss beyond what the medication provides. The drug itself is the primary driver of weight loss.
StrongSupportsVERY_HIGH confidence
In all the STEP studies, despite the varying intestines of the behavioral programs, weight loss was very similar. For the first time, there may be a suggestion that these behavioral programs might not increase weight reduction beyond the effect of semaglutide.
Why this rating
Based on multiple phase-III, randomized, double-blind, placebo-controlled trials (STEP 1-8).
Source
The Impact Once-Weekly Semaglutide 2.4 mg Will Have on Clinical Practice: A Focus on the STEP Trials
Khaled Alabduljabbar et al. · Nutrients · 2022
narrative_review · n=5828Cited 22×
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