Research
Hormonal
Metformin (850 mg twice daily) reduces the incidence of type 2 diabetes by 31% compared to placebo in high-risk adults, with greater efficacy in individuals with a BMI >= 35 kg/m2 and fasting glucose 110–125 mg/dL.
If you are at high risk for type 2 diabetes, metformin (850 mg twice daily) can reduce your risk by 31%. However, it is most effective if you have a BMI of 35 or higher or a fasting glucose between 110-125 mg/dL. Lifestyle changes remain more effective overall.
StrongQualifiesVERY_HIGH confidence
Adherence to metformin was ~70%, and it reduced diabetes by 31%... Metformin was effective only in participants with BMI >= 35 kg/m2 and in those with fasting glucose 110–125 mg/dL at baseline.
Why this rating
Large-scale, multi-center, randomized controlled trial (RCT).
Source
The Diabetes Prevention Program and Its Outcomes Study: NIDDK’s Journey Into the Prevention of Type 2 Diabetes and Its Public Health Impact
Jill P. Crandall et al. · Diabetes Care · 2025
narrative_review · n=3234Cited 20×
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