Hormonal
Once-weekly subcutaneous semaglutide 2.4 mg, used as an adjunct to lifestyle intervention, significantly reduces the 10-year risk of developing type 2 diabetes in adults with overweight or obesity compared to placebo.
If you have obesity or overweight with related health issues, adding once-weekly semaglutide 2.4 mg to your lifestyle changes can significantly lower your 10-year risk of developing type 2 diabetes compared to lifestyle changes alone. This benefit is most pronounced in those with higher baseline risk or prediabetes, and maintaining the treatment appears necessary to sustain these lower risk scores.
This analysis suggests that semaglutide 2.4 mg as an adjunct to lifestyle intervention may lower the risk of developing T2D in people with overweight (with weight-related comorbidities) or obesity, particularly in those individuals with high CMDS scores at baseline.
Why this rating
Based on post hoc analysis of three large, randomized, double-blind, placebo-controlled phase 3 trials (STEP 1, 4, 5) with rigorous statistical modeling (CMDS).
Source
Effect of semaglutide 2.4 mg once weekly on 10‐year type 2 diabetes risk in adults with overweight or obesity
Lua Wilkinson et al. · Obesity · 2023
DOI 10.1002/oby.23842
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →