Hormonal
Discontinuation of GLP-1 therapy leads to rapid and substantial weight regain, often returning to near baseline levels within one year, highlighting the chronic nature of obesity treatment.
GLP-1 medications are not a one-time fix for obesity. If you stop taking them, you will likely regain most of the weight you lost. This suggests that obesity management with these drugs is intended to be long-term, similar to managing blood pressure or cholesterol.
When GLP-1s are stopped, weight regain is common—typically nearly to baseline within one year [18–20]. Notably, this has been observed even with accompanying use of conventional nutritional counseling and/or behavioral therapy.
Why this rating
Consistently observed across multiple controlled and observational studies cited.
Source
Nutritional priorities to support GLP-1 therapy for obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society
Dariush Mozaffarian et al. · Obesity Pillars · 2025
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