Hormonal
Peri-operative use of GLP-1 receptor agonists delays gastric emptying, increasing the risk of retained gastric contents and pulmonary aspiration during anesthesia, particularly in patients without diabetes or those recently initiating therapy.
If you take GLP-1 medications (like Ozempic or Wegovy) before surgery, tell your anesthesiologist immediately. These drugs slow stomach emptying, which can cause dangerous aspiration during anesthesia. You may need to fast longer or follow a clear-liquid diet for 24 hours before your procedure, even if it is elective. Do not assume standard fasting rules apply.
In conclusion, GLP-1 RAs delay gastric emptying, with the potential risk of aspiration with peri-operative use.
Why this rating
Based on retrospective audits, case reports, and small observational studies rather than large RCTs.
Source
Considerations of delayed gastric emptying with peri‐operative use of glucagon‐like peptide‐1 receptor agonists
Lisa M. Raven et al. · The Medical Journal of Australia · 2023
DOI 10.5694/mja2.52170
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