Hormonal
Intensive lifestyle interventions improve Type 2 Diabetes remission rates and reduce medication usage, even if they do not significantly reduce cardiovascular mortality events compared to standard care.
Even if your weight loss isn't dramatic enough to eliminate all cardiovascular risk factors, the metabolic benefits of lifestyle change are profound. You can achieve diabetes remission (normal blood sugar without meds) and significantly reduce your reliance on glucose-lowering and blood pressure medications. Work with your doctor to adjust medications as you lose weight to avoid side effects like hypoglycemia. The goal is to improve your metabolic health, which often happens before major cardiovascular events are prevented.
Significantly greater rates of remission of T2D were observed among those in the ILI; at Year 1 follow-up, an 11.2% remission rate was reported in the ILI group compared with 2.0% in the control group... there was no difference in the primary outcome of cardiovascular deaths and events between those in the intervention and control groups.
Why this rating
Based on the same large, long-term RCT (Look AHEAD).
Source
Evidence-based lifestyle interventions for obesity and Type 2 diabetes: The Look AHEAD intensive lifestyle intervention as exemplar.
Delia Smith West et al. · American Psychologist · 2016
DOI 10.1037/a0040394
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →