Hormonal
Once-weekly efpeglenatide significantly reduces HbA1c and body weight in patients with type 2 diabetes and obesity, with a safety profile characterized by mild-to-moderate gastrointestinal side effects and low hypoglycemia risk.
Efpeglenatide is a once-weekly (or monthly) injection that helps lower blood sugar and lose weight in people with type 2 diabetes and obesity. It is generally well-tolerated, with common side effects like nausea being mild and temporary. It offers a convenient alternative to daily medications and has cardiovascular benefits for high-risk patients.
The findings of these studies consistently indicate that efpeglenatide significantly reduces hemoglobin A1C (HbA1C), fasting plasma glucose (FPG), and body weight in patients with T2DM and obesity... The safety profile is similar to that of other GLP-1 RAs, with mild-to-moderate gastrointestinal side effects being the most common and a low risk of hypoglycemia, especially in patients not using insulin or sulfonylureas.
Why this rating
Based on a systematic review of 8 studies including RCTs, though some had moderate bias risk.
Source
Efficacy and Safety of Efpeglenatide in Patients With Type 2 Diabetes and Obesity: A Systematic Review
Neha Narayan et al. · Cureus · 2025
DOI 10.7759/cureus.77089
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