Research
Hormonal
Cagrilintide, a long-acting amylin analogue, produces dose-dependent weight loss in adults with obesity, with the highest dose (4.5 mg) showing greater weight loss than Liraglutide 3.0 mg.
Cagrilintide is a once-weekly injection that mimics the hormone amylin to reduce appetite and slow digestion. In a 26-week trial, the highest dose (4.5 mg) led to an average 10.8% weight loss, outperforming Liraglutide 3.0 mg. It is currently in Phase 2 development for adults with obesity.
GoodSupportsHIGH confidence
At the highest dose of 4.5 mg, Cagrilintide demonstrated greater weight loss than the liraglutide group (− 10.8% vs − 9.0%, respectively) [13].
Why this rating
Based on Phase 2 RCTs; promising but less extensive data than Tirzepatide's Phase 3 trials.
Source
Pharmacotherapy for chronic obesity management: a look into the future
Mariana Abdel-Malek et al. · Internal and Emergency Medicine · 2023
DOI 10.1007/s11739-023-03237-4
narrative_reviewCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide, a dual GIP/GLP-1 receptor agonist, produces substantial, dose-dependent weight loss in adults with obesity (mean 15-21% over 72 weeks) and superior glycemic control compared to placebo and other GLP-1 agonists.Strong
- Setmelanotide, a melanocortin-4 receptor (MC4R) agonist, produces significant weight loss in patients with specific genetic obesity disorders (POMC, LEPR, or PCSK1 deficiency).Good
- Combination therapy of Cagrilintide (amylin analogue) and Semaglutide (GLP-1 agonist) produces synergistic weight loss, with the 2.4 mg Cagrilintide dose achieving 17.1% weight loss over 20 weeks.Moderate
Related findings · Hormonal
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- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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