Hormonal
Dual incretin agonists (GLP-1/GIP) and triple agonists (GLP-1/GIP/Glucagon) show superior efficacy in reducing liver fat, inflammation, and fibrosis compared to GLP-1 mono-agonists in animal models, suggesting potential for enhanced clinical outcomes in MASLD.
Research suggests that newer 'dual' (GLP-1/GIP) and 'triple' (GLP-1/GIP/Glucagon) agonists may offer even greater benefits for liver health than current GLP-1 drugs, particularly in reducing liver fat and inflammation. These are still largely in clinical trials or early adoption phases for liver disease. If standard GLP-1 therapy is insufficient, discuss these newer multi-agonist options with your hepatologist or endocrinologist, keeping in mind that long-term human data for liver-specific outcomes is still being gathered.
Importantly, the combination of GLP-1RAs with GIP and/or glucagon RAs may be even more effective via synergistic mechanisms in amelioration of metabolic, biochemical, and histological parameters of MASLD
Why this rating
Based primarily on animal studies (mouse models) with some early human trial data for dual agonists; triple agonist human data is limited.
Source
Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature
Lampros Chrysavgis et al. · International Journal of Molecular Sciences · 2024
DOI 10.3390/ijms25073832
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