Research
Hormonal
Semaglutide 2.4 mg weekly produces significant weight loss (14.9% reduction) in individuals with obesity.
Semaglutide 2.4 mg is a once-weekly injection approved for chronic weight management. It significantly reduces body weight by mimicking the GLP-1 hormone, which helps control appetite. Common side effects include gastrointestinal issues, which often improve over time.
GoodSupportsHIGH confidence
In STEP 1, Semaglutide users achieved a 14.9% weight reduction compared to 2.4% in the placebo group at week 68 (ETD: −12.4%; 95% CI: −13.4% to −11.5%; P < 0.001).
Why this rating
Based on STEP 1, a phase III RCT with significant results.
Source
Approved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article
Wael R. Sidrak et al. · Indian Journal of Endocrinology and Metabolism · 2024
DOI 10.4103/ijem.ijem_442_23
narrative_reviewCited 15×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide, a dual GLP-1 and GIP receptor agonist, produces significant weight loss (17.8% placebo-subtracted) in individuals with obesity without diabetes.Good
- Retatrutide, a triple GLP-1/GCGR/GIP receptor agonist, produces significant weight loss (-22.1% placebo-subtracted) in individuals with obesity.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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