Hormonal
Treatment with second-generation antipsychotics (SGAs) significantly increases hunger and appetite, with an odds ratio of 1.51 for appetite increase compared to controls.
If you are taking second-generation antipsychotics (like olanzapine, clozapine, or risperidone), expect an increase in hunger and appetite. This is a known biological side effect linked to how the drug interacts with brain receptors, not a lack of willpower. Discuss this with your prescriber; they may monitor your diet or adjust medication to manage this increased drive to eat.
Hunger was increased in participants treated with SGAs with an odds ratio for appetite increase of 1.51 (95% CI [1.04, 1.97]; z = 6.40; p < 0.001).
Why this rating
Based on a systematic review and meta-analysis of 92 papers with 11,274 participants, though heterogeneity was noted.
Source
Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis
Hiba Mutwalli et al. · Journal of Psychiatric Research · 2023
DOI 10.1016/j.jpsychires.2023.02.006
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