Hormonal
Weekly subcutaneous semaglutide (titrated to 2.0 mg) significantly reduces body weight in clozapine-treated patients with schizophrenia and obesity compared to placebo over 36 weeks.
This protocol outlines a clinical trial for using semaglutide to treat obesity in people with schizophrenia taking clozapine. It is not a general recommendation but a research study. If you are interested, consult your psychiatrist about eligibility for clinical trials, as this specific intervention is currently under investigation for this population.
Based on preclinical research on the impact of antipsychotics on the GLP-1 pathway, it is expected that add-on therapy with semaglutide once a week in clozapine-treated patients diagnosed with schizophrenia spectrum disorder will result in significantly greater weight loss as a proportion of body weight at endpoint compared with placebo.
Why this rating
This is a study protocol; no results are reported, only the hypothesis and design.
Source
Effects of semaglutide on body weight in clozapine-treated people with schizophrenia and obesity: study protocol for a placebo-controlled, randomised multicentre trial (COaST)
Dan Siskind et al. · BJPsych Open · 2023
DOI 10.1192/bjo.2023.532
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →