Research
Hormonal
Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB), improves metabolic health partly by activating the endocannabinoid system (CB-1) to increase sympathetic nerve activity and promote white adipose tissue browning.
If you are considering bariatric surgery, understand that it works by changing how your body signals hunger and burns energy, not just by restricting food intake. Discuss all options with your healthcare provider.
ModerateSupportsMEDIUM confidence
the beneficial metabolic effects of Roux-en-Y gastric bypass (RYGB) surgery in diet-induced obese mice are partly attributable to increased activity of the splanchnic nerve (a part of the SNS) by activation of CB-1 which result in visceral WAT (vWAT) browning, enhanced visceral thermogenesis and increased resting metabolic rate
Why this rating
The evidence is primarily from preclinical mouse models, with limited direct human translation data provided in this review.
Source
Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose Tissue in Development and Therapy of Obesity
Andreas Till et al. · Brain Sciences · 2022
DOI 10.3390/brainsci12121646
narrative_reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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