Research
Hormonal
GLP-1 receptor agonists reduce systolic blood pressure by 2–5 mmHg and diastolic blood pressure by 1–3 mmHg, with effects more pronounced than DPP-4 inhibitors.
GLP-1 receptor agonists offer a modest blood pressure benefit (2-5 mmHg systolic) in addition to weight loss. This is a secondary benefit, not a replacement for dedicated antihypertensive therapy if needed.
GoodSupportsHIGH confidence
In general, clinical investigations of GLP-1 agonists have demonstrated reductions in SBP and DBP on average, 2–5 and 1–3 mmHg, respectively, providing supportive evidence of the favourable effects these agents have on BP.
Why this rating
Based on multiple RCTs showing consistent, albeit modest, reductions.
Source
Implications of incretin-based therapies on cardiovascular disease
Melissa E. Rotz et al. · International Journal of Clinical Practice · 2014
DOI 10.1111/ijcp.12572
systematic_reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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