Hormonal
In vitro treatment with eicosapentaenoic acid (EPA) inhibits myotube formation and overrides the stimulatory effects of 17β-estradiol (E2) on myoblast differentiation.
If you are taking hormone replacement therapy (HRT) and considering high-dose fish oil supplements, be aware that they might not work together to build muscle as expected. This lab study suggests that high levels of EPA can actually block the muscle-building benefits of estrogen. Consult your doctor before combining these, especially if muscle maintenance is a primary goal.
Independently, EPA inhibited myoblast differentiation and overrides the stimulatory effect of E2 when used in combination with E2.
Why this rating
The study uses a reliable in-vitro model (C2C12 myoblasts) with rigorous molecular analysis (qPCR, NGS), but lacks in-vivo human validation.
Source
Divergent Regulation of Myotube Formation and Gene Expression by E2 and EPA during In-Vitro Differentiation of C2C12 Myoblasts
Orly Lacham‐Kaplan et al. · International Journal of Molecular Sciences · 2020
DOI 10.3390/ijms21030745
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