Research
Macro partitioning
Genotype-matched dietary interventions (low-fat vs. low-carbohydrate) may not consistently predict weight loss success in postmenopausal women compared to general overweight populations.
Do not rely solely on genetic testing to dictate whether you should eat low-fat or low-carb. Focus on sustainable dietary patterns like DASH or MED, as genotype matching has not consistently proven superior for weight loss in recent large studies.
ModerateRefutesMEDIUM confidence
when the DIETFITS multilocus genotype pattern methodology was expanded to healthy male and female adults with overweight and obesity, there was no difference in 12-month weight loss between the low-fat and low-carbohydrate diets, and neither genotype pattern nor baseline insulin secretion was associated with the dietary effects on weight loss
Why this rating
Based on a large RCT (DIETFITS expansion) but the paper notes the lack of sex-based analysis makes it hard to parse menopause impact.
Source
Precision Nutrition for Management of Cardiovascular Disease Risk During Menopause
Hannah E. Cabre et al. · Lifestyle Genomics · 2024
DOI 10.1159/000540337
narrative_reviewCited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Adherence to the Mediterranean Diet (MED) or Dietary Approaches to Stop Hypertension (DASH) improves cardiovascular disease risk biomarkers (total and LDL cholesterol, blood pressure) and reduces oxidative stress and inflammation in postmenopausal women.Moderate
- Precision nutrition strategies, including monitoring postprandial glycemic responses and gut microbiome composition, may attenuate unfavorable cardiovascular risk factors associated with menopause.Limited
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