Hormonal
Replacing dietary fat with high-glycemic index (GI) carbohydrates increases the prevalence of hypertriglyceridemia and low HDL-cholesterol, particularly in non-obese individuals.
If you eat a high-carbohydrate diet, the quality of those carbohydrates matters significantly for your blood fats. Replacing fats with high-glycemic index carbs (like white rice or refined grains) is linked to higher triglycerides and lower 'good' HDL cholesterol. This effect is particularly strong if you are not overweight. Focus on low-GI carbohydrates and healthy fats rather than simply reducing fat intake.
Replacing fat with high-GI carbohydrate intake was associated with higher a prevalence of high TGs and low HDL-cholesterol levels in both men... and women... The associations were stronger for high-GI carbohydrates than low- or med-GI carbohydrates.
Why this rating
Large sample size (n=93,870) and rigorous statistical adjustment, but the cross-sectional design prevents causal inference.
Source
Carbohydrate Intake and Hyperlipidemia among Population with High‐Carbohydrate Diets: The Health Examinees Gem Study
Woo‐Kyoung Shin et al. · Molecular Nutrition & Food Research · 2020
DOI 10.1002/mnfr.202000379
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