Hormonal
Genetically modeled GLP-1 and GIP receptor agonism reduces fatty food liking and increases vegetarian food liking.
Genetic evidence suggests that activating GLP-1 and GIP receptors shifts food preferences away from fatty foods and towards vegetarian options. This change in food preference may contribute to the observed reduction in binge drinking.
food preference analyses revealed that BMI lowering via GIPR/GLP1R reduced fatty food liking (β = −1.58, [−2.01, −1.14], P = 1.62 × 10−12) and increased vegetarian food liking (β = 2.08, [1.17, 2.99], P = 8.22 × 10−6)
Why this rating
Extremely strong statistical significance (P < 10^-12) and consistent directional effects across multiple food categories.
Source
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study
Joshua Reitz et al. · Molecular Psychiatry · 2025
DOI 10.1038/s41380-025-03199-3
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