Research
Hormonal
Genetically modeled GLP-1 and GIP receptor agonism reduces fatty food liking and increases vegetarian food liking.
Genetic evidence suggests that activating GLP-1 and GIP receptors shifts food preferences away from fatty foods and towards vegetarian options. This change in food preference may contribute to the observed reduction in binge drinking.
StrongSupportsVERY_HIGH confidence
food preference analyses revealed that BMI lowering via GIPR/GLP1R reduced fatty food liking (β = −1.58, [−2.01, −1.14], P = 1.62 × 10−12) and increased vegetarian food liking (β = 2.08, [1.17, 2.99], P = 8.22 × 10−6)
Why this rating
Extremely strong statistical significance (P < 10^-12) and consistent directional effects across multiple food categories.
Source
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study
Joshua Reitz et al. · Molecular Psychiatry · 2025
cohort · n=1812013Cited 8×
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