Hormonal
Achieving short-term (2-year) diabetes remission in patients with obesity and type 2 diabetes is associated with significantly reduced long-term overall mortality and increased life expectancy, primarily driven by decreased cardiovascular mortality.
If you have obesity and type 2 diabetes, working towards diabetes remission (normal blood sugar without medication) is one of the most powerful things you can do for your long-term survival. This study shows that even if you only achieve remission for two years, it is linked to living longer and a significantly lower risk of dying from heart disease. You do not need to stay in remission forever to gain this longevity benefit, and you can achieve it through various means, including lifestyle changes, not just surgery.
In this post-hoc analysis of data from the SOS study, patients who achieved short-term diabetes remission had increased life expectancy and decreased cardiovascular death over up to 32 years of follow-up.
Why this rating
Prospective cohort study with very long follow-up (median 26.2 years) and large sample size, but it is a post-hoc analysis and observational, not a randomized controlled trial of the remission itself.
Source
Mortality in relation to diabetes remission in Swedish Obese Subjects – a prospective cohort study
Lena Carlsson et al. · International Journal of Surgery · 2024
DOI 10.1097/js9.0000000000001807
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →