Hormonal
Significant weight loss achieved through very low calorie diets (VLCD) or bariatric surgery can preserve and enhance beta-cell function in type 2 diabetes, particularly in patients with short disease duration.
If you have Type 2 Diabetes, especially if diagnosed recently, significant weight loss is the most effective way to restore your pancreas's ability to make insulin. This can be achieved through bariatric surgery or a strict 600-calorie daily diet for a short period (1-8 weeks). This is not just about weight loss; it is about 'resting' the beta-cells to restore their function.
Bariatric surgery and very low calorie diets show improvement in beta-cell function in many individuals.
Why this rating
Review of multiple studies with washout periods, but observational/crossover designs dominate.
Source
Beta‐cell function in type 2 diabetes (<scp>T2DM</scp>): Can it be preserved or enhanced?
Laure Sayyed Kassem et al. · Journal of Diabetes · 2023
DOI 10.1111/1753-0407.13446
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