Hormonal
Adding 250 mg of protease enzymes (ProHydrolase) to 26 g of whey protein post-resistance exercise does not increase the total amino acid exposure (AUC) or anabolic signaling (mTOR/p70S6K phosphorylation) compared to consuming 26 g of whey protein alone in trained males.
If you are taking whey protein after your workout, adding a specific protease enzyme blend (like ProHydrolase) does not provide any additional benefit for muscle protein synthesis or total amino acid absorption compared to taking whey protein by itself. You do not need to buy specialized enzyme-enhanced proteins to maximize your results; standard whey protein is sufficient.
Area under the curve amino acid analysis revealed no differences between PW and W... While no different than W, these data indicate that PW was the only group to produce elevated amino acid concentrations 30-min and 180-min post-ingestion... we observed no differences between groups in phosphorylation of signaling proteins AKT, mTOR, p70S6K...
Why this rating
Small sample size (n=10), short duration (acute study), and proprietary supplement limits generalizability, though the crossover design is robust.
Source
The Effect of ProHydrolase® on the Amino Acid and Intramuscular Anabolic Signaling Response to Resistance Exercise in Trained Males
Jeremy R. Townsend et al. · Sports · 2020
DOI 10.3390/sports8020013
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