Research
Hormonal
Discontinuation of GLP-1 receptor agonists leads to significant weight regain (up to two-thirds of lost weight) and reversal of cardiometabolic improvements.
If you stop taking GLP-1 medications, you are likely to regain a significant portion of the weight you lost. Long-term use is often necessary to maintain weight loss and metabolic benefits. Discuss a long-term plan with your provider before stopping.
GoodSupportsHIGH confidence
Unfortunately, 1 year after stopping the drug, patients regained two-thirds of the weight they had lost, and their cardiometabolic improvements returned to baseline levels.
Why this rating
Based on extension trial data cited in the paper.
Source
“Ozempic Face” in Plastic Surgery: A Systematic Review of the Literature on GLP-1 Receptor Agonist Mediated Weight Loss and Analysis of Public Perceptions
Giulia Daneshgaran et al. · Aesthetic Surgery Journal Open Forum · 2025
DOI 10.1093/asjof/ojaf056
systematic_reviewCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Hormonal
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