Hormonal
In patients with type 2 diabetes, higher diabetes severity (measured by the Individualized Metabolic Surgery score) is associated with significantly lower total body weight loss from semaglutide treatment.
If you have type 2 diabetes, your expected weight loss from semaglutide depends on how severe your diabetes is. Those with milder diabetes (better blood sugar control, no insulin) tend to lose more weight (around 8%) than those with severe diabetes (often on insulin, higher HbA1c), who lose less (around 5.5%). However, the medication still offers important health benefits for blood sugar and heart health regardless of the amount of weight lost, so it remains a recommended treatment for severe cases.
In our cohort, lower IMS severity was associated with more weight loss in patients with obesity and T2D.
Why this rating
Retrospective multicenter cohort study with a decent sample size (n=297) and statistical significance, but limited by retrospective design and lack of randomization.
Source
Weight loss outcomes with semaglutide based on diabetes severity using the individualized metabolic surgery score
Wissam Ghusn et al. · EClinicalMedicine · 2024
DOI 10.1016/j.eclinm.2024.102625
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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