Hormonal
Baseline HbA1c levels in Type 2 Diabetes patients have significantly declined over time (from ~10.6% to ~7.9%), reflecting improved glycemic control in clinical trial populations.
Blood sugar control in Type 2 Diabetes has improved significantly over the last 35 years, with average baseline HbA1c dropping from 10.6% to 7.9%. This suggests that modern detection and management strategies are more effective. However, this improvement in glucose control has not prevented the rise in obesity, meaning you must address both metrics.
Baseline HbA1c level declined with time (Rs = −0.665, P ＜ 0.0001, I2 = 99.4%). Mean baseline HbA1c decreased from 10.60% (92.35 mmol/mol) (1987) to 7.92% (63.05 mmol/mol) (2022).
Why this rating
Systematic review and meta-analysis of 427 RCTs.
Source
Trends in baseline HbA1c and body-mass index in randomised placebo-controlled trials of type 2 diabetes from 1987 to 2022: a systematic review and meta-analysis
Suiyuan Hu et al. · EClinicalMedicine · 2023
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