Hormonal
Combining dulaglutide (1.5 mg weekly) with a low-energy diet (825 kcal/day) significantly improves weight loss and glycaemic control in individuals with type 2 diabetes and obesity compared to baseline, while maintaining high adherence and tolerability.
If you have type 2 diabetes and obesity, combining a once-weekly GLP-1 medication (dulaglutide) with a strict low-calorie diet (around 825 calories/day) can lead to significant weight loss (approx. 9.5 kg) and better blood sugar control. This approach helps manage hunger, making it easier to stick to the diet. Always consult your doctor before stopping current diabetes or blood pressure medications.
Participants achieved an average weight loss of 9.5 kg and a mean reduction in haemoglobin A1c of 15.8 mmol/mol... Eighty-nine per cent of participants completed the 12-week dietary intervention.
Why this rating
Single-arm pilot study with small sample size (n=19) and no control group limits causal inference regarding the specific contribution of dulaglutide versus the diet alone.
Source
Pilot study to test the safety, tolerability and feasibility of dulaglutide during a low-energy diet for weight loss and improved glycaemic control
James A. D. Shand et al. · BMJ Nutrition Prevention & Health · 2023
DOI 10.1136/bmjnph-2023-000733
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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