Hormonal
Central obesity and increased total body fat are primary predictors of insulin resistance and the evolution of impaired glucose tolerance into frank diabetes, mediated by pro-inflammatory cytokines.
Focus on reducing central abdominal fat and overall body fat percentage, not just total body weight. Regular physical activity and dietary changes that improve body composition are crucial for preventing insulin resistance and type 2 diabetes, especially if you belong to high-risk ethnic groups or live in rapidly developing regions.
The preliminary results of this IAEA-CRP activity confirmed the increasing risk of obesity and NIDDM in developing societies due to changes in diet and physical activity patterns and suggest that total body fat and its topography are perhaps the most important predictors of the evolution of insulin resistance syndrome.
Why this rating
The paper is a progress report/supplement summarizing multiple observational studies; while consistent, it lacks long-term randomized controlled trial data for causal inference.
Source
Application of Stable Isotopic Techniques in the Prevention of Degenerative Diseases like Obesity and NIDDM in Developing Societies
Prakash Shetty et al. · Food and Nutrition Bulletin · 2002
DOI 10.1177/15648265020233s134
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