Hormonal
GLP-1 receptor agonists (semaglutide, tirzepatide) produce modest weight loss (2.3–5%) in breast cancer patients, which is significantly attenuated compared to non-cancer populations, likely due to concurrent endocrine therapy.
If you have breast cancer and are taking hormone-blocking therapy, GLP-1 drugs like semaglutide will likely help you lose some weight, but not as much as they do for people without cancer. Expect a modest loss (around 2-5%) rather than dramatic results. This is likely because your cancer treatment changes your metabolism. It appears safe regarding cancer recurrence, but discuss timing with your oncologist.
Clinical studies in BC patients have shown weight loss ranging from 2.3% to 5%, likely attenuated by concurrent endocrine therapy.
Why this rating
Based on retrospective cohort studies and abstracts, not large-scale randomized controlled trials.
Source
GLP-1 Receptor Agonists in Breast Cancer: A New Frontier in Obesity and Prognosis Management
Juliana G. Xande et al. · International Journal of Molecular Sciences · 2025
DOI 10.3390/ijms26167744
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