Macro partitioning
Patients treated with GLP-1 based therapies must increase protein intake to 1–1.5 g/kg bodyweight/day and engage in resistance training to mitigate the loss of lean body mass (LBM) and prevent sarcopenic obesity.
If you are taking a GLP-1 medication like Ozempic or Wegovy, you must eat more protein than the standard recommendation. Aim for 1 to 1.5 grams of protein per kilogram of your body weight every day. Additionally, you must lift weights or do resistance exercises at least twice a week. This combination is the only proven way to stop your body from eating its own muscle while you lose fat.
Among individuals with overweight or obesity, calculating the recommended protein intake using their actual bodyweight may lead to a significant overestimation of protein requirement... The current recommended protein intake for a patient on obesity medication is 1–1.5 g of protein per kilo of body weight... In addition to higher protein intake, addressing physical inactivity through regular exercise can further help to preserve muscle mass and functionality... resistance training (2–3 times/week, lasting ≥8 weeks) had a beneficial effect on body composition... [and] was also associated with improvements in muscle mass, muscle strength and gait speed
Why this rating
The paper is a narrative review citing multiple systematic reviews and clinical trials (e.g., STEP-1, SURMOUNT-1), providing strong observational and trial-based support.
Source
Application of nutrition interventions with GLP-1 based therapies: A narrative review of the challenges and solutions
Angela Fitch et al. · Obesity Pillars · 2025
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