Hormonal

Females with severe obesity face a disproportionately higher relative risk for stroke, total CVD, and all-cause mortality compared to males with similar obesity levels.

Women with obesity should be particularly vigilant about stroke risk, as their relative risk increases more sharply with obesity severity than men's. Regular cardiovascular screening is essential for women with higher BMI.

StrongQualifiesHIGH confidence

Compared to males, females experienced higher relative increases in the risk associated with severe obesity for outcomes stroke, CVD, and all-cause mortality (p-for-interaction: <0.001, 0.003, and <0.001, respectively).

Zeina A. Dardari et al. · Circulation · 2026

Why this rating

Large sample size allows for robust subgroup analysis by sex.

Source

Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration

Zeina A. Dardari et al. · Circulation · 2026

cohort · n=289875Cited 4×

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