Hormonal
Tirzepatide, a dual GIP/GLP-1 receptor agonist, demonstrates rapidly increasing real-world utilization as both a glucose-lowering medication and an anti-obesity medication in patients with chronic kidney disease (CKD), with initiators showing high rates of obesity and morbid obesity.
For patients with CKD, tirzepatide is increasingly being used to manage both blood sugar and weight. Real-world data indicates that doctors are prescribing it more frequently, especially for those with obesity. While clinical trials have limited CKD representation, real-world usage is high and growing.
Among 455,047 patients with CKD and T2D, tirzepatide any users increased to 4.8% in September 2023, while incident users rose from 0.8% to 8.6%. ... Tirzepatide initiators had higher rates of obesity (32.5%), and morbid obesity (44.1%) when compared with other GLMs.
Why this rating
Large observational cohort (n=455,047) with robust claims data, though limited by lack of direct lab measurements for some outcomes.
Source
Utilization Trends of Dual GIP/GLP-1 Receptor Agonist, Newer Glucose-Lowering Medications, and Anti-Obesity Medications Among Patients With Chronic Kidney Disease With and Without Type 2 Diabetes
Panupong Hansrivijit et al. · Kidney Medicine · 2025
DOI 10.1016/j.xkme.2025.101013
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